Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction

Gefitinib (Iressa) is an inhibitor of the epidermal growth factor receptor (EGFR) that has shown promising activity in the treatment of patients with non-small cell lung cancer (NSCLC). However, adverse side effects of gefitinib treatment, such as respiratory dysfunction, have limited the therapeuti...

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Detalles Bibliográficos
Autores principales: Tabara, Hiroe, Naito, Yoko, Ito, Akihiko, Katsuma, Asako, Sakurai, Minami A., Ohno, Shouichi, Shimizu, Hiroyuki, Yabuta, Norikazu, Nojima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192135/
https://www.ncbi.nlm.nih.gov/pubmed/22022498
http://dx.doi.org/10.1371/journal.pone.0026034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192135/
https://www.ncbi.nlm.nih.gov/pubmed/22022498
http://dx.doi.org/10.1371/journal.pone.0026034

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