SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals

Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease in infants characterized by muscle weakness and impaired synaptic transmission. We report here severe structural and functional alterations in the organization of the organelles...

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Detalles Bibliográficos
Autores principales: Torres-Benito, Laura, Neher, Margret Feodora, Cano, Raquel, Ruiz, Rocio, Tabares, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192162/
https://www.ncbi.nlm.nih.gov/pubmed/22022549
http://dx.doi.org/10.1371/journal.pone.0026164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192162/
https://www.ncbi.nlm.nih.gov/pubmed/22022549
http://dx.doi.org/10.1371/journal.pone.0026164

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