Gene Targeting of the Cysteine Peptidase Cathepsin H Impairs Lung Surfactant in Mice

BACKGROUND: The 11 human cysteine cathepsins are proteases mainly located in the endolysosomal compartment of all cells and within the exocytosis pathways of some secretory cell types. Cathepsin H (Ctsh) has amino- and endopeptidase activities. In vitro studies have demonstrated Ctsh involvement in...

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Detalles Bibliográficos
Autores principales: Bühling, Frank, Kouadio, Martin, Chwieralski, Caroline E., Kern, Ursula, Hohlfeld, Jens M., Klemm, Nicole, Friedrichs, Nicole, Roth, Wera, Deussing, Jan M., Peters, Christoph, Reinheckel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192174/
https://www.ncbi.nlm.nih.gov/pubmed/22022579
http://dx.doi.org/10.1371/journal.pone.0026247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192174/
https://www.ncbi.nlm.nih.gov/pubmed/22022579
http://dx.doi.org/10.1371/journal.pone.0026247

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