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Gene Targeting of the Cysteine Peptidase Cathepsin H Impairs Lung Surfactant in Mice
BACKGROUND: The 11 human cysteine cathepsins are proteases mainly located in the endolysosomal compartment of all cells and within the exocytosis pathways of some secretory cell types. Cathepsin H (Ctsh) has amino- and endopeptidase activities. In vitro studies have demonstrated Ctsh involvement in...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192174/ https://www.ncbi.nlm.nih.gov/pubmed/22022579 http://dx.doi.org/10.1371/journal.pone.0026247 |