Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

DNA mismatch repair enzymes (e.g., MSH2) maintain genomic integrity, and their deficiency predisposes to several human cancers and to drug resistance. We found that leukemia cells from a substantial proportion of patients (~11%) with newly diagnosed acute lymphoblastic leukemia (ALL) have low or und...

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Detalles Bibliográficos
Autores principales: Diouf, Barthelemy, Cheng, Qing, Krynetskaia, Natalia F., Yang, Wenjian, Cheok, Meyling, Pei, Deqing, Fan, Yiping, Cheng, Cheng, Krynetskiy, Evgeny Y., Geng, Hui, Chen, Siying, Thierfelder, William E., Mullighan, Charles G., Downing, James R., Hsieh, Peggy, Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192247/
https://www.ncbi.nlm.nih.gov/pubmed/21946537
http://dx.doi.org/10.1038/nm.2430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192247/
https://www.ncbi.nlm.nih.gov/pubmed/21946537
http://dx.doi.org/10.1038/nm.2430

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