The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

Calcineurin inhibitors (CNIs) are immunosuppressive drugs, which are used widely to prevent rejection of transplanted organs and treat autoimmune disease. Hypertension and renal tubule dysfunction, including hyperkalemia, hypercalciuria, and acidosis often complicate their use(1,2). These side effec...

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Detalles Bibliográficos
Autores principales: Hoorn, Ewout J., Walsh, Stephen B., McCormick, James A., Fürstenberg, Antje, Yang, Chao-Ling, Roeschel, Tom, Paliege, Alexander, Howie, Alexander J., Conley, James, Bachmann, Sebastian, Unwin, Robert J., Ellison, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192268/
https://www.ncbi.nlm.nih.gov/pubmed/21963515
http://dx.doi.org/10.1038/nm.2497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192268/
https://www.ncbi.nlm.nih.gov/pubmed/21963515
http://dx.doi.org/10.1038/nm.2497

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