Both Basic and Acidic Amino Acid Residues of IpTx(a) Are Involved in Triggering Substate of RyR1

Imperatoxin A (IpTx(a)) is known to modify the gating of skeletal ryanodine receptor (RyR1). In this paper, the ability of charged aa residues of IpTx(a) to induce substate of native RyR1 in HSR was examined. Our results show that the basic residues (e.g., Lys(19), Lys(20), Lys(22), Arg(23), and Arg...

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Detalles Bibliográficos
Autores principales: Seo, In Ra, Kang, Dae Eun, Song, Dong Woo, Kim, Do Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192407/
https://www.ncbi.nlm.nih.gov/pubmed/22007141
http://dx.doi.org/10.1155/2011/386384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192407/
https://www.ncbi.nlm.nih.gov/pubmed/22007141
http://dx.doi.org/10.1155/2011/386384

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