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Both Basic and Acidic Amino Acid Residues of IpTx(a) Are Involved in Triggering Substate of RyR1
Imperatoxin A (IpTx(a)) is known to modify the gating of skeletal ryanodine receptor (RyR1). In this paper, the ability of charged aa residues of IpTx(a) to induce substate of native RyR1 in HSR was examined. Our results show that the basic residues (e.g., Lys(19), Lys(20), Lys(22), Arg(23), and Arg...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192407/ https://www.ncbi.nlm.nih.gov/pubmed/22007141 http://dx.doi.org/10.1155/2011/386384 |