A Potent Inhibitor of SIK2, 3, 3′, 7-Trihydroxy-4′-Methoxyflavon (4′-O-Methylfisetin), Promotes Melanogenesis in B16F10 Melanoma Cells

Flavonoids, which are plant polyphenols, are now widely used in supplements and cosmetics. Here, we report that 4′-methylflavonoids are potent inducers of melanogenesis in B16F10 melanoma cells and in mice. We recently identified salt inducible kinase 2 (SIK2) as an inhibitor of melanogenesis via th...

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Detalles Bibliográficos
Autores principales: Kumagai, Ayako, Horike, Nanao, Satoh, Yudai, Uebi, Tatsuya, Sasaki, Tsutomu, Itoh, Yumi, Hirata, Yoshiyuki, Uchio-Yamada, Kozue, Kitagawa, Kazuo, Uesato, Shinichi, Kawahara, Hidehisa, Takemori, Hiroshi, Nagaoka, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192784/
https://www.ncbi.nlm.nih.gov/pubmed/22022544
http://dx.doi.org/10.1371/journal.pone.0026148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192784/
https://www.ncbi.nlm.nih.gov/pubmed/22022544
http://dx.doi.org/10.1371/journal.pone.0026148

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