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Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures

Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we present a novel microfluidic based cell culture me...

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Detalles Bibliográficos
Autores principales: Kunze, Anja, Valero, Ana, Zosso, Dominique, Renaud, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192785/
https://www.ncbi.nlm.nih.gov/pubmed/22022558
http://dx.doi.org/10.1371/journal.pone.0026187