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Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures
Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we present a novel microfluidic based cell culture me...
Autores principales: | Kunze, Anja, Valero, Ana, Zosso, Dominique, Renaud, Philippe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192785/ https://www.ncbi.nlm.nih.gov/pubmed/22022558 http://dx.doi.org/10.1371/journal.pone.0026187 |
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