Therapy and Long-Term Prophylaxis of Vaccinia Virus Respiratory Infections in Mice with an Adenovirus-Vectored Interferon Alpha (mDEF201)

An adenovirus 5 vector encoding for mouse interferon alpha, subtype 5 (mDEF201) was evaluated for efficacy against lethal vaccinia virus (WR strain) respiratory infections in mice. mDEF201 was administered as a single intranasal treatment either prophylactically or therapeutically at doses of 10(6)...

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Detalles Bibliográficos
Autores principales: Smee, Donald F., Wong, Min-Hui, Russell, Andrew, Ennis, Jane, Turner, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192798/
https://www.ncbi.nlm.nih.gov/pubmed/22022603
http://dx.doi.org/10.1371/journal.pone.0026330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192798/
https://www.ncbi.nlm.nih.gov/pubmed/22022603
http://dx.doi.org/10.1371/journal.pone.0026330

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