Quantifying Intramolecular Binding in Multivalent Interactions: A Structure-Based Synergistic Study on Grb2-Sos1 Complex

Numerous signaling proteins use multivalent binding to increase the specificity and affinity of their interactions within the cell. Enhancement arises because the effective binding constant for multivalent binding is larger than the binding constants for each individual interaction. We seek to gain...

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Detalles Bibliográficos
Autores principales: Sethi, Anurag, Goldstein, Byron, Gnanakaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192808/
https://www.ncbi.nlm.nih.gov/pubmed/22022247
http://dx.doi.org/10.1371/journal.pcbi.1002192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192808/
https://www.ncbi.nlm.nih.gov/pubmed/22022247
http://dx.doi.org/10.1371/journal.pcbi.1002192

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