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Modelling Reveals Kinetic Advantages of Co-Transcriptional Splicing

Messenger RNA splicing is an essential and complex process for the removal of intron sequences. Whereas the composition of the splicing machinery is mostly known, the kinetics of splicing, the catalytic activity of splicing factors and the interdependency of transcription, splicing and mRNA 3′ end f...

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Detalles Bibliográficos
Autores principales: Aitken, Stuart, Alexander, Ross D., Beggs, Jean D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192812/
https://www.ncbi.nlm.nih.gov/pubmed/22022255
http://dx.doi.org/10.1371/journal.pcbi.1002215