Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes

Nonsense Mediated Decay (NMD) degrades transcripts that contain a premature STOP codon resulting from mistranscription or missplicing. However NMD's surveillance of gene expression varies in efficiency both among and within human genes. Previous work has shown that the intron content of human g...

Descripción completa

Detalles Bibliográficos
Autores principales: Cusack, Brian P., Arndt, Peter F., Duret, Laurent, Crollius, Hugues Roest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192821/
https://www.ncbi.nlm.nih.gov/pubmed/22022272
http://dx.doi.org/10.1371/journal.pgen.1002276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192821/
https://www.ncbi.nlm.nih.gov/pubmed/22022272
http://dx.doi.org/10.1371/journal.pgen.1002276

Ejemplares similares