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Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3
Fibroblast growth factor receptor 3 (FGFR3) is a major negative regulator of bone growth that inhibits the proliferation and differentiation of growth plate chondrocytes. Activating mutations of its c isoform cause dwarfism in humans; somatic mutations can drive oncogenic transformation in multiple...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192865/ https://www.ncbi.nlm.nih.gov/pubmed/21865593 http://dx.doi.org/10.1091/mbc.E11-01-0080 |