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Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3

Fibroblast growth factor receptor 3 (FGFR3) is a major negative regulator of bone growth that inhibits the proliferation and differentiation of growth plate chondrocytes. Activating mutations of its c isoform cause dwarfism in humans; somatic mutations can drive oncogenic transformation in multiple...

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Detalles Bibliográficos
Autores principales:	Degnin, Catherine R., Laederich, Melanie B., Horton, William A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192865/ https://www.ncbi.nlm.nih.gov/pubmed/21865593 http://dx.doi.org/10.1091/mbc.E11-01-0080

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