Cargando…

Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO

BACKGROUND: The fractional concentration of nitric oxide in exhaled air (FENO) is used as a biomarker of eosinophilic airway inflammation. FENO is increased in patients with asthma. The relationship between subjective asthma symptoms and airway inflammation is an important issue. We expected that th...

Descripción completa

Detalles Bibliográficos
Autores principales: Ishizuka, Tamotsu, Matsuzaki, Shinichi, Aoki, Haruka, Yatomi, Masakiyo, Kamide, Yosuke, Hisada, Takeshi, Tsuburai, Takahiro, Dobashi, Kunio, Ohshima, Kihachi, Akiyama, Kazuo, Mori, Masatomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193803/
https://www.ncbi.nlm.nih.gov/pubmed/21923950
http://dx.doi.org/10.1186/1710-1492-7-15
_version_ 1782213888485359616
author Ishizuka, Tamotsu
Matsuzaki, Shinichi
Aoki, Haruka
Yatomi, Masakiyo
Kamide, Yosuke
Hisada, Takeshi
Tsuburai, Takahiro
Dobashi, Kunio
Ohshima, Kihachi
Akiyama, Kazuo
Mori, Masatomo
author_facet Ishizuka, Tamotsu
Matsuzaki, Shinichi
Aoki, Haruka
Yatomi, Masakiyo
Kamide, Yosuke
Hisada, Takeshi
Tsuburai, Takahiro
Dobashi, Kunio
Ohshima, Kihachi
Akiyama, Kazuo
Mori, Masatomo
author_sort Ishizuka, Tamotsu
collection PubMed
description BACKGROUND: The fractional concentration of nitric oxide in exhaled air (FENO) is used as a biomarker of eosinophilic airway inflammation. FENO is increased in patients with asthma. The relationship between subjective asthma symptoms and airway inflammation is an important issue. We expected that the subjective asthma symptoms in women might be different from those in men. Therefore, we investigated the gender differences of asthma symptoms and FENO in a survey of asthma prevalence in university students. METHODS: The information about asthma symptoms was obtained from answers to the European Community Respiratory Health Survey (ECRHS) questionnaire, and FENO was measured by an offline method in 640 students who were informed of this study and consented to participate. RESULTS: The prevalence of asthma symptoms on the basis of data obtained from 584 students (266 men and 318 women), ranging in age from 18 to 24 years, was analyzed. Wheeze, chest tightness, an attack of shortness of breath, or an attack of cough within the last year was observed in 13.2% of 584 students. When 38.0 ppb was used as the cut-off value of FENO to make the diagnosis of asthma, the sensitivity was 86.8% and the specificity was 74.0%. FENO was ≥ 38.0 ppb in 32.7% of students. FENO was higher in men than in women. The prevalence of asthma symptoms estimated by considering FENO was 7.2%; the prevalence was greater in men (9.4%) than women (5.3%). A FENO ≥ 38.0 ppb was common in students who reported wheeze, but not in students, especially women, who reported cough attacks. CONCLUSIONS: The prevalence of asthma symptoms in university students age 18 to 24 years in Japan was estimated to be 7.2% on the basis of FENO levels as well as subjective symptoms. Gender differences were observed in both FENO levels and asthma symptoms reflecting the presence of eosinophilic airway inflammation. TRIAL REGISTRATION NUMBER: UMIN000003244
format Online
Article
Text
id pubmed-3193803
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-31938032011-10-16 Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO Ishizuka, Tamotsu Matsuzaki, Shinichi Aoki, Haruka Yatomi, Masakiyo Kamide, Yosuke Hisada, Takeshi Tsuburai, Takahiro Dobashi, Kunio Ohshima, Kihachi Akiyama, Kazuo Mori, Masatomo Allergy Asthma Clin Immunol Research BACKGROUND: The fractional concentration of nitric oxide in exhaled air (FENO) is used as a biomarker of eosinophilic airway inflammation. FENO is increased in patients with asthma. The relationship between subjective asthma symptoms and airway inflammation is an important issue. We expected that the subjective asthma symptoms in women might be different from those in men. Therefore, we investigated the gender differences of asthma symptoms and FENO in a survey of asthma prevalence in university students. METHODS: The information about asthma symptoms was obtained from answers to the European Community Respiratory Health Survey (ECRHS) questionnaire, and FENO was measured by an offline method in 640 students who were informed of this study and consented to participate. RESULTS: The prevalence of asthma symptoms on the basis of data obtained from 584 students (266 men and 318 women), ranging in age from 18 to 24 years, was analyzed. Wheeze, chest tightness, an attack of shortness of breath, or an attack of cough within the last year was observed in 13.2% of 584 students. When 38.0 ppb was used as the cut-off value of FENO to make the diagnosis of asthma, the sensitivity was 86.8% and the specificity was 74.0%. FENO was ≥ 38.0 ppb in 32.7% of students. FENO was higher in men than in women. The prevalence of asthma symptoms estimated by considering FENO was 7.2%; the prevalence was greater in men (9.4%) than women (5.3%). A FENO ≥ 38.0 ppb was common in students who reported wheeze, but not in students, especially women, who reported cough attacks. CONCLUSIONS: The prevalence of asthma symptoms in university students age 18 to 24 years in Japan was estimated to be 7.2% on the basis of FENO levels as well as subjective symptoms. Gender differences were observed in both FENO levels and asthma symptoms reflecting the presence of eosinophilic airway inflammation. TRIAL REGISTRATION NUMBER: UMIN000003244 BioMed Central 2011-09-19 /pmc/articles/PMC3193803/ /pubmed/21923950 http://dx.doi.org/10.1186/1710-1492-7-15 Text en Copyright ©2011 Ishizuka et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ishizuka, Tamotsu
Matsuzaki, Shinichi
Aoki, Haruka
Yatomi, Masakiyo
Kamide, Yosuke
Hisada, Takeshi
Tsuburai, Takahiro
Dobashi, Kunio
Ohshima, Kihachi
Akiyama, Kazuo
Mori, Masatomo
Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO
title Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO
title_full Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO
title_fullStr Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO
title_full_unstemmed Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO
title_short Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO
title_sort prevalence of asthma symptoms based on the european community respiratory health survey questionnaire and feno in university students: gender differences in symptoms and feno
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193803/
https://www.ncbi.nlm.nih.gov/pubmed/21923950
http://dx.doi.org/10.1186/1710-1492-7-15
work_keys_str_mv AT ishizukatamotsu prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT matsuzakishinichi prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT aokiharuka prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT yatomimasakiyo prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT kamideyosuke prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT hisadatakeshi prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT tsuburaitakahiro prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT dobashikunio prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT ohshimakihachi prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT akiyamakazuo prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno
AT morimasatomo prevalenceofasthmasymptomsbasedontheeuropeancommunityrespiratoryhealthsurveyquestionnaireandfenoinuniversitystudentsgenderdifferencesinsymptomsandfeno