Silencing GADD153/CHOP Gene Expression Protects against Alzheimer's Disease-Like Pathology Induced by 27-Hydroxycholesterol in Rabbit Hippocampus

Endoplasmic reticulum (ER) stress is suggested to play a key role in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). Sustained ER stress leads to activation of the growth arrest and leucine zipper transcription factor, DNA damage inducible gene 153 (gadd153; a...

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Detalles Bibliográficos
Autores principales: Prasanthi, Jaya R. P., Larson, Tyler, Schommer, Jared, Ghribi, Othman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194795/
https://www.ncbi.nlm.nih.gov/pubmed/22046282
http://dx.doi.org/10.1371/journal.pone.0026420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194795/
https://www.ncbi.nlm.nih.gov/pubmed/22046282
http://dx.doi.org/10.1371/journal.pone.0026420

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