The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

Bacteria, fungi, protozoa, chromista and plants all harbor homologues of Hsp104, a AAA+ ATPase that collaborates with Hsp70 and Hsp40 to promote protein disaggregation and reactivation. Curiously, however, metazoa do not possess an Hsp104 homologue. Thus, whether animal cells renature large protein...

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Detalles Bibliográficos
Autor principal: Shorter, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194798/
https://www.ncbi.nlm.nih.gov/pubmed/22022600
http://dx.doi.org/10.1371/journal.pone.0026319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194798/
https://www.ncbi.nlm.nih.gov/pubmed/22022600
http://dx.doi.org/10.1371/journal.pone.0026319

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