Hepatocyte IKK2 Protects Mdr2(−/−) Mice from Chronic Liver Failure

Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2 (−/−)) develop chronic periductular inflammation and cholestatic liver disease resulting in the development of hepatocellular carcinoma (HCC). Inhibition of NF-κB by expression of an IκBα super-repressor (IκBαSR) transgen...

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Detalles Bibliográficos
Autores principales: Ehlken, Hanno, Kondylis, Vangelis, Heinrichsdorff, Jan, Ochoa-Callejero, Laura, Roskams, Tania, Pasparakis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195080/
https://www.ncbi.nlm.nih.gov/pubmed/22022477
http://dx.doi.org/10.1371/journal.pone.0025942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195080/
https://www.ncbi.nlm.nih.gov/pubmed/22022477
http://dx.doi.org/10.1371/journal.pone.0025942

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