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Hepatocyte IKK2 Protects Mdr2(−/−) Mice from Chronic Liver Failure
Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2 (−/−)) develop chronic periductular inflammation and cholestatic liver disease resulting in the development of hepatocellular carcinoma (HCC). Inhibition of NF-κB by expression of an IκBα super-repressor (IκBαSR) transgen...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195080/ https://www.ncbi.nlm.nih.gov/pubmed/22022477 http://dx.doi.org/10.1371/journal.pone.0025942 |