Purinergic Signaling Induces Cyclooxygenase-1-Dependent Prostanoid Synthesis in Microglia: Roles in the Outcome of Excitotoxic Brain Injury

Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis, the role of COX-1 is not clearly understood....

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Detalles Bibliográficos
Autores principales: Anrather, Josef, Gallo, Eduardo F., Kawano, Takayuki, Orio, Marcello, Abe, Takato, Gooden, Camile, Zhou, Ping, Iadecola, Costantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195085/
https://www.ncbi.nlm.nih.gov/pubmed/22022466
http://dx.doi.org/10.1371/journal.pone.0025916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195085/
https://www.ncbi.nlm.nih.gov/pubmed/22022466
http://dx.doi.org/10.1371/journal.pone.0025916

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