Inverse agonism and its therapeutic significance

A large number of G-protein-coupled receptors (GPCRs) show varying degrees of basal or constitutive activity. This constitutive activity is usually minimal in natural receptors but is markedly observed in wild type and mutated (naturally or induced) receptors. According to conventional two-state dru...

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Detalles Bibliográficos
Autores principales: Khilnani, Gurudas, Khilnani, Ajeet Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Educational Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195115/
https://www.ncbi.nlm.nih.gov/pubmed/22021988
http://dx.doi.org/10.4103/0253-7613.84947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195115/
https://www.ncbi.nlm.nih.gov/pubmed/22021988
http://dx.doi.org/10.4103/0253-7613.84947

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