Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
OBJECTIVE: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. MATERIALS AND METHODS: Hepatotoxicity was induced in male Wistar rats by in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195128/ https://www.ncbi.nlm.nih.gov/pubmed/22022001 http://dx.doi.org/10.4103/0253-7613.84973 |
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author | Anusha, M. Venkateswarlu, M. Prabhakaran, V. Taj, S. Shareen Kumari, B. Pushpa Ranganayakulu, D. |
author_facet | Anusha, M. Venkateswarlu, M. Prabhakaran, V. Taj, S. Shareen Kumari, B. Pushpa Ranganayakulu, D. |
author_sort | Anusha, M. |
collection | PubMed |
description | OBJECTIVE: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. MATERIALS AND METHODS: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride (0.1 ml/kg b.w for 14 days). The aqueous extract of P. oleracea in combination with lycopene (50 mg/kg b.w) was administered to the experimental animals at two selected doses for 14 days. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (Alk.P), total bilirubin (TB), total protein (TP) and total cholesterol (TC)], pentobarbitone induced sleeping time (PST) and histopathological studies of liver. RESULTS: Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study. CONCLUSIONS: The oral administration of P. oleracea in combination with lycopene significantly ameliorates CCl(4) hepatotoxicity in rats. |
format | Online Article Text |
id | pubmed-3195128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31951282011-10-21 Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats Anusha, M. Venkateswarlu, M. Prabhakaran, V. Taj, S. Shareen Kumari, B. Pushpa Ranganayakulu, D. Indian J Pharmacol Research Article OBJECTIVE: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. MATERIALS AND METHODS: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride (0.1 ml/kg b.w for 14 days). The aqueous extract of P. oleracea in combination with lycopene (50 mg/kg b.w) was administered to the experimental animals at two selected doses for 14 days. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (Alk.P), total bilirubin (TB), total protein (TP) and total cholesterol (TC)], pentobarbitone induced sleeping time (PST) and histopathological studies of liver. RESULTS: Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study. CONCLUSIONS: The oral administration of P. oleracea in combination with lycopene significantly ameliorates CCl(4) hepatotoxicity in rats. Medknow Publications 2011 /pmc/articles/PMC3195128/ /pubmed/22022001 http://dx.doi.org/10.4103/0253-7613.84973 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Anusha, M. Venkateswarlu, M. Prabhakaran, V. Taj, S. Shareen Kumari, B. Pushpa Ranganayakulu, D. Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats |
title | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats |
title_full | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats |
title_fullStr | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats |
title_full_unstemmed | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats |
title_short | Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats |
title_sort | hepatoprotective activity of aqueous extract of portulaca oleracea in combination with lycopene in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195128/ https://www.ncbi.nlm.nih.gov/pubmed/22022001 http://dx.doi.org/10.4103/0253-7613.84973 |
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