Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats

OBJECTIVE: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. MATERIALS AND METHODS: Hepatotoxicity was induced in male Wistar rats by in...

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Autores principales: Anusha, M., Venkateswarlu, M., Prabhakaran, V., Taj, S. Shareen, Kumari, B. Pushpa, Ranganayakulu, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195128/
https://www.ncbi.nlm.nih.gov/pubmed/22022001
http://dx.doi.org/10.4103/0253-7613.84973
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author Anusha, M.
Venkateswarlu, M.
Prabhakaran, V.
Taj, S. Shareen
Kumari, B. Pushpa
Ranganayakulu, D.
author_facet Anusha, M.
Venkateswarlu, M.
Prabhakaran, V.
Taj, S. Shareen
Kumari, B. Pushpa
Ranganayakulu, D.
author_sort Anusha, M.
collection PubMed
description OBJECTIVE: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. MATERIALS AND METHODS: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride (0.1 ml/kg b.w for 14 days). The aqueous extract of P. oleracea in combination with lycopene (50 mg/kg b.w) was administered to the experimental animals at two selected doses for 14 days. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (Alk.P), total bilirubin (TB), total protein (TP) and total cholesterol (TC)], pentobarbitone induced sleeping time (PST) and histopathological studies of liver. RESULTS: Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study. CONCLUSIONS: The oral administration of P. oleracea in combination with lycopene significantly ameliorates CCl(4) hepatotoxicity in rats.
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spelling pubmed-31951282011-10-21 Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats Anusha, M. Venkateswarlu, M. Prabhakaran, V. Taj, S. Shareen Kumari, B. Pushpa Ranganayakulu, D. Indian J Pharmacol Research Article OBJECTIVE: To investigate the hepatoprotective activity of the aqueous extract of the aerial parts of Portulaca oleracea (P. oleracea) in combination with lycopene against carbon tetrachloride induced hepatotoxicity in rats. MATERIALS AND METHODS: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of carbon tetrachloride (0.1 ml/kg b.w for 14 days). The aqueous extract of P. oleracea in combination with lycopene (50 mg/kg b.w) was administered to the experimental animals at two selected doses for 14 days. The hepatoprotective activity of the combination was evaluated by the liver function marker enzymes in the serum [aspartate transaminases (AST), alanine transaminases (ALT), alkaline phosphatase (Alk.P), total bilirubin (TB), total protein (TP) and total cholesterol (TC)], pentobarbitone induced sleeping time (PST) and histopathological studies of liver. RESULTS: Both the treatment groups showed hepatoprotective effect against carbon tetrachloride induced hepatotoxicity by significantly restoring the levels of serum enzymes to normal which was comparable to that of silymarin group. Besides, the results obtained from PST and histopathological results also support the study. CONCLUSIONS: The oral administration of P. oleracea in combination with lycopene significantly ameliorates CCl(4) hepatotoxicity in rats. Medknow Publications 2011 /pmc/articles/PMC3195128/ /pubmed/22022001 http://dx.doi.org/10.4103/0253-7613.84973 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Anusha, M.
Venkateswarlu, M.
Prabhakaran, V.
Taj, S. Shareen
Kumari, B. Pushpa
Ranganayakulu, D.
Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
title Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
title_full Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
title_fullStr Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
title_full_unstemmed Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
title_short Hepatoprotective activity of aqueous extract of Portulaca oleracea in combination with lycopene in rats
title_sort hepatoprotective activity of aqueous extract of portulaca oleracea in combination with lycopene in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195128/
https://www.ncbi.nlm.nih.gov/pubmed/22022001
http://dx.doi.org/10.4103/0253-7613.84973
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