Effects of Kynurenine Pathway Inhibition on NAD(+) Metabolism and Cell Viability in Human Primary Astrocytes and Neurons

The kynurenine pathway (KP) is the principle route of L-Tryptophan (TRP) metabolism, producing several neurotoxic and neuroprotective metabolic precursors before complete oxidation to the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD(+)). KP inhibition may prove therapeutic in...

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Detalles Bibliográficos
Autores principales: Braidy, Nady, Guillemin, Gilles J., Grant, Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195218/
https://www.ncbi.nlm.nih.gov/pubmed/22084601
http://dx.doi.org/10.4137/IJTR.S7052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195218/
https://www.ncbi.nlm.nih.gov/pubmed/22084601
http://dx.doi.org/10.4137/IJTR.S7052

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