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Effects of Kynurenine Pathway Inhibition on NAD(+) Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
The kynurenine pathway (KP) is the principle route of L-Tryptophan (TRP) metabolism, producing several neurotoxic and neuroprotective metabolic precursors before complete oxidation to the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD(+)). KP inhibition may prove therapeutic in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Libertas Academica
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195218/ https://www.ncbi.nlm.nih.gov/pubmed/22084601 http://dx.doi.org/10.4137/IJTR.S7052 |