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Protein Kinase A-mediated Serine 35 Phosphorylation Dissociates Histone H1.4 from Mitotic Chromosome

Global histone H1 phosphorylation correlates with cell cycle progression. However, the function of site-specific H1 variant phosphorylation remains unclear. Our mass spectrometry analysis revealed a novel N-terminal phosphorylation of the major H1 variant H1.4 at serine 35 (H1.4S35ph), which accumul...

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Detalles Bibliográficos
Autores principales: Chu, Chi-Shuen, Hsu, Pang-Hung, Lo, Pei-Wen, Scheer, Elisabeth, Tora, Laszlo, Tsai, Hang-Jen, Tsai, Ming-Daw, Juan, Li-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195632/
https://www.ncbi.nlm.nih.gov/pubmed/21852232
http://dx.doi.org/10.1074/jbc.M111.228064