Cargando…

Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function

BACKGROUND: APP expression misregulation can cause genetic Alzheimer's disease (AD). Recent evidences support the hypothesis that polymorphisms located in microRNA (miRNA) target sites could influence the risk of developing neurodegenerative disorders such as Parkinson's disease (PD) and f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Delay, Charlotte, Calon, Frédéric, Mathews, Paul, Hébert, Sébastien S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195754/ https://www.ncbi.nlm.nih.gov/pubmed/21982160 http://dx.doi.org/10.1186/1750-1326-6-70

Ejemplares similares

MicroRNAs and Alzheimer's Disease Mouse Models: Current Insights and Future Research Avenues
por: Delay, Charlotte, et al.
Publicado: (2011)

MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms
por: Delay, Charlotte, et al.
Publicado: (2014)

Prediction of viral microRNA precursors based on human microRNA precursor sequence and structural features
por: Kumar, Shiva, et al.
Publicado: (2009)

Relationship between single nucleotide polymorphisms in the 3′UTR of amyloid precursor protein and risk of Alzheimer’s disease and its mechanism
por: Zhou, Qiong, et al.
Publicado: (2019)

Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex
por: Crenshaw, Ezekiel, et al.
Publicado: (2015)

Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines
por: Hackl, Matthias, et al.
Publicado: (2012)

Repression-free utrophin-A 5’UTR variants
por: Malik, Debasish, et al.
Publicado: (2019)

Amyloid Beta and MicroRNAs in Alzheimer’s Disease
por: Amakiri, Nnana, et al.
Publicado: (2019)

Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease
por: Tremblay, Cyntia, et al.
Publicado: (2017)

microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice
por: Hernandez-Rapp, Julia, et al.
Publicado: (2016)

Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers
por: Dorval, Véronique, et al.
Publicado: (2013)

New highly sensitive rodent and human tests for soluble amyloid precursor protein alpha quantification: preclinical and clinical applications in Alzheimer’s disease
por: Rose, Christiane, et al.
Publicado: (2012)

A Novel Heterozygous Missense Variant in the CIAO1 Gene in a Family with Alzheimer’s Disease: The Val67Ile Variant Promotes the Interaction of CIAO1 and Amyloid-β Protein Precursor
por: Nan, Haitian, et al.
Publicado: (2021)

Amyloid Precursor Protein and Alzheimer’s Disease
por: Orobets, Kseniia S., et al.
Publicado: (2023)

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
por: Serneels, Lutgarde, et al.
Publicado: (2020)

Alternative Splicing Generates Different 5′ UTRs in OCT4B Variants
por: Poursani, Ensieh M., et al.
Publicado: (2017)

5′-UTR and 3′-UTR Regulation of MICB Expression in Human Cancer Cells by Novel microRNAs
por: Wongfieng, Wipaporn, et al.
Publicado: (2017)

The relationship between the evolution of microRNA targets and the length of their UTRs
por: Cheng, Chao, et al.
Publicado: (2009)

Multiple Copies of microRNA Binding Sites in Long 3′UTR Variants Regulate Axonal Translation
por: Farberov, Luba, et al.
Publicado: (2023)

Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions
por: Petry, Franck R., et al.
Publicado: (2014)

Functional variants of TIM-3/HAVCR2 3′UTR in lymphoblastoid cell lines
por: Pu, Feifei, et al.
Publicado: (2018)

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β
por: Schonrock, Nicole, et al.
Publicado: (2010)

Identifications of conserved 7-mers in 3'-UTRs and microRNAs in Drosophila
por: Gu, Jin, et al.
Publicado: (2007)

Copper binding to the Alzheimer’s disease amyloid precursor protein
por: Kong, Geoffrey K.-W., et al.
Publicado: (2007)

Extrapolative microRNA precursor based SSR mining from tea EST database in respect to agronomic traits
por: Hazra, Anjan, et al.
Publicado: (2017)

A Variant in a MicroRNA Complementary Site in the 3′UTR of the KIT Oncogene Increases Risk of Acral Melanoma
por: Godshalk, Sirie E., et al.
Publicado: (2010)

Genetic Variations Creating MicroRNA Target Sites in the FXN 3′-UTR Affect Frataxin Expression in Friedreich Ataxia
por: Bandiera, Simonetta, et al.
Publicado: (2013)

Characterization of the 3'UTR of the BTD gene and identification of regulatory elements and microRNAs
por: Silva, Gerda Cristal Villalba, et al.
Publicado: (2022)

SAGE detects microRNA precursors
por: Ge, Xijin, et al.
Publicado: (2006)

Red neurons in ovine polioencephalomalacia (cerebrocortical necrosis) are strongly amyloid precursor protein immunopositive
por: Finnie, John W., et al.
Publicado: (2022)

Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation
por: Tournissac, Marine, et al.
Publicado: (2019)

MicroRNA binding mediated Functional sequence variant in 3′-UTR of DNA repair Gene XPC in Age-related Cataract
por: Zou, Xi, et al.
Publicado: (2018)

MicroRNAs and the Regulation of Tau Metabolism
por: Hébert, Sébastien S., et al.
Publicado: (2012)

MicroRNA-196a & microRNA-101 expression in Barrett's oesophagus in patients with medically and surgically treated gastro-oesophageal reflux
por: Haiart, Sebastien, et al.
Publicado: (2011)

Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer’s disease
por: Reveret, Louise, et al.
Publicado: (2023)

Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers
por: Dufort-Gervais, Julien, et al.
Publicado: (2020)

Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
por: Willén, Katarina, et al.
Publicado: (2017)

The Influence of 3′UTRs on MicroRNA Function Inferred from Human SNP Data
por: Hu, Zihua, et al.
Publicado: (2011)

PACCMIT/PACCMIT-CDS: identifying microRNA targets in 3′ UTRs and coding sequences
por: Šulc, Miroslav, et al.
Publicado: (2015)

Mining the 3′UTR of Autism-implicated Genes for SNPs Perturbing MicroRNA Regulation
por: Vaishnavi, Varadharajan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v7b7bcp8gq7qilscriv4qoiqqa