Live Cell Calcium Imaging Combined with siRNA Mediated Gene Silencing Identifies Ca(2+) Leak Channels in the ER Membrane and their Regulatory Mechanisms

In mammalian cells, the endoplasmic reticulum (ER) plays a key role in protein biogenesis as well as in calcium signalling(1). The heterotrimeric Sec61 complex in the ER membrane provides an aqueous path for newly-synthesized polypeptides into the lumen of the ER. Recent work from various laboratori...

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Detalles Bibliográficos
Autores principales: Lang, Sven, Schäuble, Nico, Cavalié, Adolfo, Zimmermann, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2011
Materias:
Cellular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196168/
https://www.ncbi.nlm.nih.gov/pubmed/21775954
http://dx.doi.org/10.3791/2730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196168/
https://www.ncbi.nlm.nih.gov/pubmed/21775954
http://dx.doi.org/10.3791/2730

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