Tryptophan in Alcoholism Treatment I:  Kynurenine Metabolites Inhibit the Rat Liver Mitochondrial Low K(m) Aldehyde Dehydrogenase Activity, Elevate Blood Acetaldehyde Concentration and Induce Aversion to Alcohol

Aims: The aims were to provide proofs of mechanism and principle by establishing the ability of kynurenine metabolites to inhibit the liver mitochondrial low K(m) aldehyde dehydrogenase (ALDH) activity after administration and in vivo, and to induce aversion to alcohol. Methods: Kynurenic acid (KA),...

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Detalles Bibliográficos
Autores principales: Badawy, Abdulla A.-B., Bano, Samina, Steptoe, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Pharmacology and Cell Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196366/
https://www.ncbi.nlm.nih.gov/pubmed/21896552
http://dx.doi.org/10.1093/alcalc/agr134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196366/
https://www.ncbi.nlm.nih.gov/pubmed/21896552
http://dx.doi.org/10.1093/alcalc/agr134

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