Identification and Characterization of Mechanism of Action of P61-E7, a Novel Phosphine Catalysis-Based Inhibitor of Geranylgeranyltransferase-I

Small molecule inhibitors of protein geranylgeranyltransferase-I (GGTase-I) provide a promising type of anticancer drugs. Here, we first report the identification of a novel tetrahydropyridine scaffold compound, P61-E7, and define effects of this compound on pancreatic cancer cells. P61-E7 was ident...

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Detalles Bibliográficos
Autores principales: Chan, Lai N., Fiji, Hannah D. G., Watanabe, Masaru, Kwon, Ohyun, Tamanoi, Fuyuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196516/
https://www.ncbi.nlm.nih.gov/pubmed/22028818
http://dx.doi.org/10.1371/journal.pone.0026135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196516/
https://www.ncbi.nlm.nih.gov/pubmed/22028818
http://dx.doi.org/10.1371/journal.pone.0026135

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