Compromising the Unfolded Protein Response Induces Autophagy-Mediated Cell Death in Multiple Myeloma Cells

OBJECTIVE: To determine whether the Unfolded Protein Response (UPR) sensors (PERK, ATF6 and IRE-1) can be targeted to promote death of Multiple Myeloma (MM) cells. METHODS: We have knocked-down separately each UPR stress sensor in human MM cell lines using RNA interference and followed MM cell death...

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Detalles Bibliográficos
Autores principales: Michallet, Anne-Sophie, Mondiere, Paul, Taillardet, Morgan, Leverrier, Yann, Genestier, Laurent, Defrance, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196518/
https://www.ncbi.nlm.nih.gov/pubmed/22028791
http://dx.doi.org/10.1371/journal.pone.0025820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196518/
https://www.ncbi.nlm.nih.gov/pubmed/22028791
http://dx.doi.org/10.1371/journal.pone.0025820

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