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Broad-Spectrum Antiviral Activity of RNA Interference against Four Genotypes of Japanese Encephalitis Virus Based on Single MicroRNA Polycistrons

Japanese encephalitis virus (JEV), a neurotropic mosquito-borne flavivirus, causes acute viral encephalitis and neurologic disease with a high fatality rate in humans and a range of animals. Small interfering RNA (siRNA) is a powerful antiviral agent able to inhibit JEV replication. However, the hig...

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Detalles Bibliográficos
Autores principales: Wu, Zhiqiang, Xue, Ying, Wang, Bei, Du, Jiang, Jin, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196537/
https://www.ncbi.nlm.nih.gov/pubmed/22028851
http://dx.doi.org/10.1371/journal.pone.0026304