Targeted Gene-Silencing Reveals the Functional Significance of Myocardin Signaling in the Failing Heart

BACKGROUND: Myocardin (MYOCD), a potent transcriptional coactivator of smooth muscle (SM) and cardiac genes, is upregulated in failing myocardium in animal models and human end-stage heart failure (HF). However, the molecular and functional consequences of myocd upregulation in HF are still unclear....

Descripción completa

Detalles Bibliográficos
Autores principales: Torrado, Mario, Iglesias, Raquel, Centeno, Alberto, López, Eduardo, Mikhailov, Alexander T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196561/
https://www.ncbi.nlm.nih.gov/pubmed/22028870
http://dx.doi.org/10.1371/journal.pone.0026392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196561/
https://www.ncbi.nlm.nih.gov/pubmed/22028870
http://dx.doi.org/10.1371/journal.pone.0026392

Ejemplares similares