Cargando…

Targeted Gene-Silencing Reveals the Functional Significance of Myocardin Signaling in the Failing Heart

BACKGROUND: Myocardin (MYOCD), a potent transcriptional coactivator of smooth muscle (SM) and cardiac genes, is upregulated in failing myocardium in animal models and human end-stage heart failure (HF). However, the molecular and functional consequences of myocd upregulation in HF are still unclear....

Descripción completa

Detalles Bibliográficos
Autores principales:	Torrado, Mario, Iglesias, Raquel, Centeno, Alberto, López, Eduardo, Mikhailov, Alexander T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196561/ https://www.ncbi.nlm.nih.gov/pubmed/22028870 http://dx.doi.org/10.1371/journal.pone.0026392

Ejemplares similares

In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors
por: Mikhailov, Alexander T., et al.
Publicado: (2012)

Identification of Candidate Genes Potentially Relevant to Chamber-Specific Remodeling in Postnatal Ventricular Myocardium
por: Torrado, Mario, et al.
Publicado: (2010)

Myocardin in biology and disease
por: Miano, Joseph M
Publicado: (2015)

Pitx2c Is Reactivated in the Failing Myocardium and Stimulates Myf5 Expression in Cultured Cardiomyocytes
por: Torrado, Mario, et al.
Publicado: (2014)

Myocardin Family Members Drive Formation of Caveolae
por: Krawczyk, Katarzyna K., et al.
Publicado: (2015)

A myocardin-adjacent lncRNA balances SRF-dependent gene transcription in the heart
por: Anderson, Douglas M., et al.
Publicado: (2021)

Synergistic Activation of Cardiac Genes by Myocardin and Tbx5
por: Wang, Chunbo, et al.
Publicado: (2011)

Myocardin ablation in a cardiac-renal rat model
por: Mittal, Anupam, et al.
Publicado: (2019)

Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis
por: Xiang, Yuan, et al.
Publicado: (2017)

Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
por: Mughal, Wajihah, et al.
Publicado: (2018)

A MicroRNA-Transcription Factor Blueprint for Early Atrial Arrhythmogenic Remodeling
por: Torrado, Mario, et al.
Publicado: (2015)

High glucose downregulates myocardin expression in rat glomerular mesangial cells via the ERK signaling pathway
por: Li, Ming, et al.
Publicado: (2017)

Arp5 is a key regulator of myocardin in smooth muscle cells
por: Morita, Tsuyoshi, et al.
Publicado: (2014)

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice
por: Houweling, Arjan C., et al.
Publicado: (2019)

Correction to: Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
por: Mughal, Wajihah, et al.
Publicado: (2019)

Regulation of the Muscarinic M(3) Receptor by Myocardin-Related Transcription Factors
por: Liu, Li, et al.
Publicado: (2021)

YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation
por: Zheng, Jian-Pu, et al.
Publicado: (2020)

Erratum: Regulation of the Muscarinic M(3) Receptor by Myocardin-Related Transcription Factors
por: Frontiers Production Office,
Publicado: (2021)

Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors
por: Liu, Li, et al.
Publicado: (2021)

Progerin mislocalizes myocardin-related transcription factor in Hutchinson–Guilford Progeria syndrome
por: von Kleeck, Ryan, et al.
Publicado: (2022)

SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation
por: Liang, Min, et al.
Publicado: (2022)

Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension
por: Zhou, Ning, et al.
Publicado: (2017)

Myocardin-Related Transcription Factors and SRF are required for cytoskeletal dynamics, invasion and experimental metastasis
por: Medjkane, Souhila, et al.
Publicado: (2009)

Upregulation of actin cytoskeleton via myocardin leads to increased expression of type 1 collagen
por: Shi, Zengdun, et al.
Publicado: (2017)

miR-1/133a Clusters Cooperatively Specify the Cardiomyogenic Lineage by Adjustment of Myocardin Levels during Embryonic Heart Development
por: Wystub, Katharina, et al.
Publicado: (2013)

The Failing Heart
por: Wells, S. Russell
Publicado: (1907)

Beta-blocker/ACE inhibitor therapy differentially impacts the steady state signaling landscape of failing and non-failing hearts
por: Sorrentino, Andrea, et al.
Publicado: (2022)

Interrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes
por: Gorey, Mark-Alexander, et al.
Publicado: (2022)

WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner
por: Su, Fei, et al.
Publicado: (2023)

Signaling cascades in the failing heart and emerging therapeutic strategies
por: He, Xin, et al.
Publicado: (2022)

The Clinical Significance of Failing Sight
por: Ramsay, A. Maitland
Publicado: (1922)

Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes
por: Chiu, Chiung-Zuan, et al.
Publicado: (2010)

Effects of cyclic stretch on the molecular regulation of myocardin in rat aortic vascular smooth muscle cells
por: Chiu, Chiung-Zuan, et al.
Publicado: (2013)

Dual Regulation of Myocardin Expression by Tumor Necrosis Factor-α in Vascular Smooth Muscle Cells
por: Singh, Pavneet, et al.
Publicado: (2014)

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
por: Shiwen, Xu, et al.
Publicado: (2015)

Nexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP
por: Zhu, Baoyi, et al.
Publicado: (2018)

Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle
por: Zhu, Baoyi, et al.
Publicado: (2017)

Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors
por: Liu, Li, et al.
Publicado: (2022)

Myocardin/microRNA-30a/Beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy
por: Shi, Danyang, et al.
Publicado: (2022)

Myocardin‐related transcription factor A drives ROS‐fueled expansion of hepatic stellate cells by regulating p38‐MAPK signalling
por: Dong, Wenhui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i7chktecsl3smi5f0hcv85roj7