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Progranulin, a Glycoprotein Deficient in Frontotemporal Dementia, Is a Novel Substrate of Several Protein Disulfide Isomerase Family Proteins

The reduced production or activity of the cysteine-rich glycoprotein progranulin is responsible for about 20% of cases of familial frontotemporal dementia. However, little is known about the molecular mechanisms that govern the level and secretion of progranulin. Here we show that progranulin is exp...

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Detalles Bibliográficos
Autores principales: Almeida, Sandra, Zhou, Lijuan, Gao, Fen-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196579/
https://www.ncbi.nlm.nih.gov/pubmed/22028881
http://dx.doi.org/10.1371/journal.pone.0026454