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Brain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's disease

Parkinson's disease (PD) is histologically well defined by its characteristic degeneration of dopaminergic neurons in the substantia nigra pars compacta. Remarkably, divergent PD-related mutations can generate comparable brain region specific pathologies. This indicates that some intrinsic regi...

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Detalles Bibliográficos
Autores principales: Diedrich, Madeleine, Kitada, Tohru, Nebrich, Grit, Koppelstaetter, Andrea, Shen, Jie, Zabel, Claus, Klose, Joachim, Mao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196908/
https://www.ncbi.nlm.nih.gov/pubmed/21943346
http://dx.doi.org/10.1186/1477-5956-9-59