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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

RNA viruses use RNA dependent RNA polymerases to replicate their genomes. The intrinsically high error rate of these enzymes is a large contributor to the generation of extreme population diversity that facilitates virus adaptation and evolution. Increasing evidence shows that the intrinsic error ra...

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Detalles Bibliográficos
Autores principales: Beaucourt, Stéphanie, Bordería, Antonio V., Coffey, Lark L., Gnädig, Nina F., Sanz-Ramos, Marta, Beeharry, Yasnee, Vignuzzi, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197063/
https://www.ncbi.nlm.nih.gov/pubmed/21712796
http://dx.doi.org/10.3791/2953