Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

[Image: see text] A modular system for the construction of radiometalated antibodies was developed based on the bioorthogonal cycloaddition reaction between 3-(4-benzylamino)-1,2,4,5-tetrazine and the strained dienophile norbornene. The well-characterized, HER2-specific antibody trastuzumab and the...

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Detalles Bibliográficos
Autores principales: Zeglis, Brian M., Mohindra, Priya, Weissmann, Gabriel I., Divilov, Vadim, Hilderbrand, Scott A., Weissleder, Ralph, Lewis, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197258/
https://www.ncbi.nlm.nih.gov/pubmed/21877749
http://dx.doi.org/10.1021/bc200288d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197258/
https://www.ncbi.nlm.nih.gov/pubmed/21877749
http://dx.doi.org/10.1021/bc200288d

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