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Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels–Alder Click Chemistry

[Image: see text] A modular system for the construction of radiometalated antibodies was developed based on the bioorthogonal cycloaddition reaction between 3-(4-benzylamino)-1,2,4,5-tetrazine and the strained dienophile norbornene. The well-characterized, HER2-specific antibody trastuzumab and the...

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Detalles Bibliográficos
Autores principales:	Zeglis, Brian M., Mohindra, Priya, Weissmann, Gabriel I., Divilov, Vadim, Hilderbrand, Scott A., Weissleder, Ralph, Lewis, Jason S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197258/ https://www.ncbi.nlm.nih.gov/pubmed/21877749 http://dx.doi.org/10.1021/bc200288d

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