E4BP4 facilitates glucocorticoid-evoked apoptosis of human leukemic CEM cells via upregulation of Bim

BACKGROUND: Synthetic GCs serve as therapeutic agents for some lymphoid leukemias because of their ability to induce transcriptional changes via the GC receptor (GR) and trigger apoptosis. Upregulation of the BH3-only member of Bcl-2 family proteins, Bim, has been shown to be essential for GC-evoked...

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Detalles Bibliográficos
Autores principales: Beach, Jessica A, Nary, Laura J, Hirakawa, Yasuko, Holland, Eli, Hovanessian, Rebeka, Medh, Rheem D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197565/
https://www.ncbi.nlm.nih.gov/pubmed/21975218
http://dx.doi.org/10.1186/1750-2187-6-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197565/
https://www.ncbi.nlm.nih.gov/pubmed/21975218
http://dx.doi.org/10.1186/1750-2187-6-13

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