Cargando…

Tumor Suppressor Protein p53 Recruits Human Sin3B/HDAC1 Complex for Down-Regulation of Its Target Promoters in Response to Genotoxic Stress

Master regulator protein p53, popularly known as the “guardian of genome” is the hub for regulation of diverse cellular pathways. Depending on the cell type and severity of DNA damage, p53 protein mediates cell cycle arrest or apoptosis, besides activating DNA repair, which is apparently achieved by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bansal, Nidhi, Kadamb, Rama, Mittal, Shilpi, Vig, Leena, Sharma, Raisha, Dwarakanath, Bilikere S., Saluja, Daman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197607/ https://www.ncbi.nlm.nih.gov/pubmed/22028823 http://dx.doi.org/10.1371/journal.pone.0026156

Ejemplares similares

Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes
por: Kadamb, Rama, et al.
Publicado: (2015)

Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root
por: Srivastava, Rakhi, et al.
Publicado: (2011)

The Sin3A/MAD1 Complex, through Its PAH2 Domain, Acts as a Second Repressor of Retinoic Acid Receptor Beta Expression in Breast Cancer Cells
por: Dahiya, Nisha Rani, et al.
Publicado: (2022)

Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A–PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1
por: Kadamb, Rama, et al.
Publicado: (2021)

SIN-3 as a key determinant of lifespan and its sex dependent differential role on healthspan in Caenorhabditis elegans
por: Pandey, Renu, et al.
Publicado: (2018)

Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice
por: Singh, Saurabh, et al.
Publicado: (2015)

SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans
por: Konwar, Chandrika, et al.
Publicado: (2022)

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy
por: Gupta, Seema, et al.
Publicado: (2017)

Emerging concepts in cancer therapy: Mechanisms of resistance
por: Gupta, Seema, et al.
Publicado: (2022)

Differential action of polyunsaturated fatty acids and eicosanoids on bleomycin-induced cytotoxicity to neuroblastoma cells and lymphocytes
por: Polavarapu, Sailaja, et al.
Publicado: (2017)

Integrative Modeling of a Sin3/HDAC Complex Sub-structure
por: Banks, Charles A.S., et al.
Publicado: (2020)

Role of autophagy in tumor response to radiation: Implications for improving radiotherapy
por: Roy, Amrita, et al.
Publicado: (2022)

MD-1, a poly herbal formulation indicated in diabetes mellitus ameliorates glucose uptake and inhibits adipogenesis – an in vitro study
por: Telapolu, Srivani, et al.
Publicado: (2018)

Genotoxicity reduction in bagasse waste of sugar industry by earthworm technology
por: Bhat, Sartaj Ahmad, et al.
Publicado: (2016)

Transcription suppression is mediated by the HDAC1–Sin3 complex in Xenopus nucleoplasmic extract
por: Quaas, Colleen E., et al.
Publicado: (2022)

PKA cuts down on HDAC4 signaling
por: Short, Ben
Publicado: (2011)

Technological Advancements in External Beam Radiation Therapy (EBRT): An Indispensable Tool for Cancer Treatment
por: Koka, Krishna, et al.
Publicado: (2022)

Enhanced Glycolysis Confers Resistance Against Photon but Not Carbon Ion Irradiation in Human Glioma Cell Lines
por: Vashishta, Mohit, et al.
Publicado: (2023)

Prevalence of Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis infection in pregnant adolescent women and its association with pregnancy outcomes
por: Ghope, Priti, et al.
Publicado: (2014)

Comparative analysis of syndromic and PCR-based diagnostic assay reveals misdiagnosis/ overtreatment for trichomoniasis based on subjective judgment in symptomatic patients
por: Sonkar, Subash Chandra, et al.
Publicado: (2016)

Identification of Genetic Suppressors of the Sin3A Knockdown Wing Phenotype
por: Swaminathan, Aishwarya, et al.
Publicado: (2012)

Non-monotonic changes in clonogenic cell survival induced by disulphonated aluminum phthalocyanine photodynamic treatment in a human glioma cell line
por: Gupta, Seema, et al.
Publicado: (2010)

Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response
por: Choi, Hyo-Kyoung, et al.
Publicado: (2015)

Th1-Biased Immunomodulation and Therapeutic Potential of Artemisia annua in Murine Visceral Leishmaniasis
por: Islamuddin, Mohammad, et al.
Publicado: (2015)

T-Regulatory Cells In Tumor Progression And Therapy
por: Verma, Amit, et al.
Publicado: (2019)

Technological advancements in cancer diagnostics: Improvements and limitations
por: Pulumati, Akhil, et al.
Publicado: (2023)

Differential HDAC1 and 2 Recruitment by Members of the MIER Family
por: Derwish, Roya, et al.
Publicado: (2017)

Multiple sexually transmitted co-infections are associated with adverse reproductive outcomes in asymptomatic adolescent pregnant women; A Prospective cohort study
por: Wasnik, Kirti, et al.
Publicado: (2022)

Improved management can be achieved by introducing additional parameters in the syndromic diagnosis of nonviral sexually transmitted infections at low-resource settings
por: Sonkar, Subash C., et al.
Publicado: (2021)

Corrigendum: Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response
por: Choi, Hyo-Kyoung, et al.
Publicado: (2015)

Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice
por: Farooque, Abdullah, et al.
Publicado: (2014)

Pattern Recognition Receptors in Cancer Progression and Metastasis
por: Pandey, Sanjay, et al.
Publicado: (2015)

Interplay Between Metabolism and Oncogenic Process: Role of microRNAs
por: Arora, Aastha, et al.
Publicado: (2015)

Upregulated necroptosis-pathway-associated genes are unfavorable prognostic markers in low-grade glioma and glioblastoma multiforme
por: Dong, Yuanli, et al.
Publicado: (2019)

Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain
por: Chandru, Aditya, et al.
Publicado: (2018)

Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer
por: Gupta, Shilpi, et al.
Publicado: (2015)

Esculetin releases maturation arrest and induces terminal differentiation in leukemic blast cells by altering the Wnt signaling axes
por: Mathur, Ankit, et al.
Publicado: (2023)

Down-regulation of HDAC3 inhibits growth of cholangiocarcinoma by inducing apoptosis
por: Zhang, Mingming, et al.
Publicado: (2017)

HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts
por: Warnon, Céline, et al.
Publicado: (2021)

Constitutive activation and overexpression of NF-κB/c-Rel in conjunction with p50 contribute to aggressive tongue tumorigenesis
por: Gupta, Shilpi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_prmfqg0gfmhbm2chh9ll3ntiqk