Dominant-Negative Mechanism of Leukemogenic PAX5 Fusions

PAX5 encodes a master regulator of B-cell development. It fuses to other genes associated with acute lymphoblastoid leukemia (ALL). These fusion products are potent dominant-negative (DN) inhibitors of wild-type PAX5 resulting in a blockade of B-cell differentiation. Here, we show that multimerizati...

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Detalles Bibliográficos
Autores principales: Kawamata, Norihiko, Pennella, Mario A., Woo, Jennifer L., Berk, Arnold J., Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197879/
https://www.ncbi.nlm.nih.gov/pubmed/21765475
http://dx.doi.org/10.1038/onc.2011.291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197879/
https://www.ncbi.nlm.nih.gov/pubmed/21765475
http://dx.doi.org/10.1038/onc.2011.291

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