CONDITIONING FOR HEMATOPOIETIC TRANSPLANTATION ACTIVATES THE COMPLEMENT CASCADE AND INDUCES A PROTEOLYTIC ENVIRONMENT IN BONE MARROW – A NOVEL ROLE FOR BIOACTIVE LIPIDS AND SOLUBLE C5b-C9 AS HOMING FACTORS

We have observed that conditioning for hematopoietic transplantation by lethal irradiation induces a proteolytic microenvironment in bone marrow (BM) that activates the complement cascade (CC). As a result, BM is enriched for proteolytic enzymes and the soluble form of the terminal product of CC act...

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Detalles Bibliográficos
Autores principales: Kim, Chi Hwa, Wu, Wan, Wysoczynski, Marcin, Abdel-Latif, Ahmed, Sunkara, Manjula, Morris, Andrew, Kucia, Magda, Ratajczak, Janina, Ratajczak, Mariusz Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197954/
https://www.ncbi.nlm.nih.gov/pubmed/21769103
http://dx.doi.org/10.1038/leu.2011.185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197954/
https://www.ncbi.nlm.nih.gov/pubmed/21769103
http://dx.doi.org/10.1038/leu.2011.185

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