Abrogation of MMP-9 Gene Protects Against the Development of Retinopathy in Diabetic Mice by Preventing Mitochondrial Damage

OBJECTIVE: In the development of diabetic retinopathy, mitochondrial dysfunction is considered to play an important role in the apoptosis of retinal capillary cells. Diabetes activates matrix metalloproteinase-9 (MMP-9) in the retina and its capillary cells, and activated MMP-9 becomes proapoptotic....

Descripción completa

Detalles Bibliográficos
Autores principales: Kowluru, Renu A., Mohammad, Ghulam, dos Santos, Julia M., Zhong, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198054/
https://www.ncbi.nlm.nih.gov/pubmed/21933988
http://dx.doi.org/10.2337/db11-0816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198054/
https://www.ncbi.nlm.nih.gov/pubmed/21933988
http://dx.doi.org/10.2337/db11-0816

Ejemplares similares