Targeted Inhibition of Calpain Reduces Myocardial Hypertrophy and Fibrosis in Mouse Models of Type 1 Diabetes

OBJECTIVE: Recently we have shown that calpain-1 activation contributes to cardiomyocyte apoptosis induced by hyperglycemia. This study was undertaken to investigate whether targeted disruption of calpain would reduce myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. RESEARCH D...

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Detalles Bibliográficos
Autores principales: Li, Ying, Ma, Jian, Zhu, Huaqing, Singh, Manpreet, Hill, David, Greer, Peter A., Arnold, J. Malcolm, Abel, E. Dale, Peng, Tianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198063/
https://www.ncbi.nlm.nih.gov/pubmed/21911754
http://dx.doi.org/10.2337/db10-1333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198063/
https://www.ncbi.nlm.nih.gov/pubmed/21911754
http://dx.doi.org/10.2337/db10-1333

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