Cargando…

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

OBJECTIVE: To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy. RESEARCH DESIGN AND METHODS: Diabetes was induced in Nrf2(+/+)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Hongting, Whitman, Samantha A., Wu, Wei, Wondrak, Georg T., Wong, Pak K., Fang, Deyu, Zhang, Donna D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Pharmacology and Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198067/ https://www.ncbi.nlm.nih.gov/pubmed/22025779 http://dx.doi.org/10.2337/db11-0807

Ejemplares similares

An Essential Role of NRF2 in Diabetic Wound Healing
por: Long, Min, et al.
Publicado: (2016)

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy
por: Jiang, Tao, et al.
Publicado: (2010)

Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin
por: Rojo de la Vega, Montserrat, et al.
Publicado: (2018)

Sinapic Acid Ameliorates the Progression of Streptozotocin (STZ)-Induced Diabetic Nephropathy in Rats via NRF2/HO-1 Mediated Pathways
por: Alaofi, Ahmed L.
Publicado: (2020)

PTGS-2–PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice
por: Vennemann, Antje, et al.
Publicado: (2012)

Investigation of Natural Compounds for Therapeutic Potential in Streptozotocin-induced Diabetic Neuroinflammation and Neuropathic Pain
por: Faheem, Muhammad, et al.
Publicado: (2022)

Topical Fluoxetine as a Novel Therapeutic That Improves Wound Healing in Diabetic Mice
por: Nguyen, Chuong Minh, et al.
Publicado: (2019)

The Antidepressant-Like Effects of Hesperidin in Streptozotocin‐Induced Diabetic Rats by Activating Nrf2/ARE/Glyoxalase 1 Pathway
por: Zhu, Xia, et al.
Publicado: (2020)

Pien-tze-huang promotes wound healing in streptozotocin-induced diabetes models associated with improving oxidative stress via the Nrf2/ARE pathway
por: Liu, Ying, et al.
Publicado: (2023)

Oral administration of NPC43 counters hyperglycemia and activates insulin receptor in streptozotocin-induced type 1 diabetic mice
por: Lan, Zi-Jian, et al.
Publicado: (2020)

Potential Therapeutic Targets of Rehmannia Formulations on Diabetic Nephropathy: A Comparative Network Pharmacology Analysis
por: Chan, Kam Wa, et al.
Publicado: (2022)

Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo
por: Rajappa, Rashmi, et al.
Publicado: (2019)

MicroRNA-146a Mimics Reduce the Peripheral Neuropathy in Type 2 Diabetic Mice
por: Liu, Xian Shuang, et al.
Publicado: (2017)

Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration
por: Gupta, Kunal, et al.
Publicado: (2013)

Nrf2 Is Crucial to Graft Survival in a Rodent Model of Heart Transplantation
por: Wu, Wei, et al.
Publicado: (2013)

Are statin trials in diabetes representative of real-world diabetes care: a population-based study on statin initiators in Finland
por: Ruokoniemi, Päivi, et al.
Publicado: (2014)

Ephrin-B2–Activated Peripheral Blood Mononuclear Cells From Diabetic Patients Restore Diabetes-Induced Impairment of Postischemic Neovascularization
por: Broquères-You, Dong, et al.
Publicado: (2012)

Durability of oral hypoglycemic agents in drug naïve patients with type 2 diabetes: report from the Swedish National Diabetes Register (NDR)
por: Ekström, Nils, et al.
Publicado: (2015)

Platelet Isoprostane Overproduction in Diabetic Patients Treated With Aspirin
por: Cangemi, Roberto, et al.
Publicado: (2012)

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds
por: Tang, Yunan, et al.
Publicado: (2013)

Investigation assessing the publicly available evidence supporting postmarketing withdrawals, revocations and suspensions of marketing authorisations in the EU since 2012
por: Lane, Samantha, et al.
Publicado: (2018)

Dorzagliatin, a Dual-Acting Glucokinase Activator, Increases Insulin Secretion and Glucose Sensitivity in Glucokinase Maturity-Onset Diabetes of the Young and Recent-Onset Type 2 Diabetes
por: Chow, Elaine, et al.
Publicado: (2023)

Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes
por: Morgantini, Cecilia, et al.
Publicado: (2011)

MG53 Does Not Manifest the Development of Diabetes in db/db Mice
por: Wang, Qiang, et al.
Publicado: (2020)

Rumex nervosus could alleviate streptozotocin-induced diabetic nephropathy in rats by activating Nrf2 signaling
por: AlMousa, Lujain A, et al.
Publicado: (2022)

Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors
por: Leicht, Simon F., et al.
Publicado: (2011)

Risk of gastrointestinal bleeding and cardiovascular events due to NSAIDs in the diabetic elderly population
por: Kim, Jungmee, et al.
Publicado: (2015)

Variation in the estimated costs of pivotal clinical benefit trials supporting the US approval of new therapeutic agents, 2015–2017: a cross-sectional study
por: Moore, Thomas J, et al.
Publicado: (2020)

Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy
por: Schuhmacher, Swenja, et al.
Publicado: (2011)

Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Lin, Yi, et al.
Publicado: (2015)

Effect of Intensive Glycemic and Blood Pressure Control on QT Prolongation in Diabetes: The ACCORD Trial
por: Singleton, Matthew J., et al.
Publicado: (2020)

Consensus validation of the POSAMINO (POtentially Serious Alcohol–Medication INteractions in Older adults) criteria
por: Holton, Alice E, et al.
Publicado: (2017)

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy
por: de Haan, Judy B.
Publicado: (2011)

Changes in drug disposition of lithium during pregnancy: a retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway
por: Westin, Andreas Austgulen, et al.
Publicado: (2017)

Algorithms for personalized therapy of type 2 diabetes: results of a web-based international survey
por: Gallo, Marco, et al.
Publicado: (2015)

Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials
por: Sosenko, Jay M., et al.
Publicado: (2020)

Antidiabetic Effects of Pterosin A, a Small-Molecular-Weight Natural Product, on Diabetic Mouse Models
por: Hsu, Feng-Lin, et al.
Publicado: (2013)

Metformin Treatment in the Period After Stroke Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes
por: Abdelsaid, Mohammed, et al.
Publicado: (2015)

Engineered Commensal Bacteria Reprogram Intestinal Cells Into Glucose-Responsive Insulin-Secreting Cells for the Treatment of Diabetes
por: Duan, Franklin F., et al.
Publicado: (2015)

Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response
por: Jiang, Tao, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7ebq4qv1cjqlmm4dofapn60bge