APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

OBJECTIVE: Insulin stimulates both nitric oxide (NO)-dependent vasodilation and endothelin-1 (ET-1)–dependent vasoconstriction. However, the cellular mechanisms that control the dual vascular effects of insulin remain unclear. This study aimed to investigate the roles of the multidomain adaptor prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yi, Cheng, Kenneth K.Y., Lam, Karen S.L., Wu, Donghai, Wang, Yu, Huang, Yu, Vanhoutte, Paul M., Sweeney, Gary, Li, Yiming, Xu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198090/
https://www.ncbi.nlm.nih.gov/pubmed/21926268
http://dx.doi.org/10.2337/db11-0666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198090/
https://www.ncbi.nlm.nih.gov/pubmed/21926268
http://dx.doi.org/10.2337/db11-0666

Ejemplares similares