Specific Glucose-Induced Control of Insulin Receptor Substrate-2 Expression Is Mediated via Ca(2+)-Dependent Calcineurin/NFAT Signaling in Primary Pancreatic Islet β-Cells

OBJECTIVE: Insulin receptor substrate-2 (IRS-2) plays an essential role in pancreatic islet β-cells by promoting growth and survival. IRS-2 turnover is rapid in primary β-cells, but its expression is highly regulated at the transcriptional level, especially by glucose. The aim was to investigate the...

Descripción completa

Detalles Bibliográficos
Autores principales: Demozay, Damien, Tsunekawa, Shin, Briaud, Isabelle, Shah, Ramila, Rhodes, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198104/
https://www.ncbi.nlm.nih.gov/pubmed/21940781
http://dx.doi.org/10.2337/db11-0341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198104/
https://www.ncbi.nlm.nih.gov/pubmed/21940781
http://dx.doi.org/10.2337/db11-0341

Ejemplares similares